The 5-minute herb and dietary supplement consult by Adriane Fugh-Berman MD

By Adriane Fugh-Berman MD

This detailed e-book provides healthiness care execs a brief connection with herbs, minerals, supplements, amino acids, probiotics, enzymes, over the counter hormones and different supplements universal via shoppers. The textual content covers claims, symptoms, medical proof, attainable merits, adversarial results, contraindications, and drug interactions.

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MECHANISM/PHARMACOKINETICS —Arnica sesquiterpenes inhibited tumor growth of Ehrlich ascites in mice and Walker 256 carcinosarcoma in rats (1). • Sesquiterpene lactones appear to interact with proteins containing thiol groups. They are known to have antiinflammatory properties and act at multiple receptor sites, suppressing prostaglandin synthesis and uncoupling oxidative phosphorylation of human polymorphonuclear neutrophils (PMNs) (1). • Antiinflammatory effects • Helenalin slows the recovery kinetics of calcium, perhaps through membrane stabilization, which may account for its toxic effects (2).

However, studies in rats showed neither an anti-implantation nor an abortifacient effect of A. sinensis root extracts (1). • Aqueous root extract of A. sinensis administered orally or intraperitoneally to mice suppressed serum titers of IgE but had no effect on IgG (1). • Several coumarins isolated from A. edulis inhibit human platelet aggregation and exhibit antitumor-promoting activity, as measured by TPA-stimulated 32Pi incorporation into phospholipids of cultured cells (7). • Volatile constituents of A.

Also phenolic acids (including ferulic and caffeic acid) and sitosterol. Evidence CLINICAL TRIALS • Although clinical trials of astragalus exist, most are uncontrolled and/or published in the Chinese medical literature (see questions and answers). • Cancer/immune stimulation —A study in 16 hemodialysis patients tested the addition of 30 mL astragalus to an intravenous drip given during dialysis visits (2 to 3 times weekly) for 2 months (1). Lymphocyte cultures from the treated group were compared with lymphocyte cultures from 15 controls (who received intravenous infusion without astragalus).

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