By Richard I. G. Holt
This ebook is the fitting source for a direction on endocrinology and diabetes, as a part of USMLE educating, and an on-going spouse in the course of postgraduate medical and clinical examine. This textbook goals to bridge the distance from uncomplicated technology education, via scientific education, to the information required for the early postgraduate years and professional education. The textual content is going past middle undergraduate clinical schooling. studying targets, containers, and concluding ‘key issues’ objective to stress the main topics.
The educating kind and presentation has been bolstered all through, and contains studying goals and “recap” hyperlinks at first of every bankruptcy that remind the reader of key findings and ideas, whereas cross-referencing makes it effortless to find similar details fast and successfully. There also are extra case reviews, with distinctive solutions using concept to practice
The first half strives to create a educated reader ready for the medical sections.
The moment half keeps a principally organ-based technique. The introductory simple technology in those chapters goals to be concise but adequate to appreciate, diagnose and deal with the linked medical disorders.
The 3rd half on diabetes and weight problems used to be completely new within the final version and those chapters have gone through the best swap here.
Contents
Preface
List of abbreviations
How to get the simplest from your textbook
Part 1: Foundations of Endocrinology
1 assessment of endocrinology
2 phone biology and hormone synthesis
three Molecular foundation of hormone action
four Investigations in endocrinology and diabetes
Part 2: Endocrinology -Biology to medical Practice
five The hypothalamus and pituitary gland
6 The adrenal gland
7 Reproductive endocrinology
eight The thyroid gland
nine Calcium and metabolic bone disorders
10 Pancreatic and gastrointestinal endocrinology and endocrine neoplasia
Part three: Diabetes and Obesity
eleven review of diabetes
12 style 1 diabetes
thirteen variety 2 diabetes
14 issues of diabetes
15 Obesity
Index
Read Online or Download Essential Endocrinology and Diabetes PDF
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Additional info for Essential Endocrinology and Diabetes
Example text
Thyrotrophin-releasing hormone (TRH), which consists of only three amino acids. g. luteinizing hormone (LH). Peptides with any degree of complexity fold into three-dimensional structures, which may contain helical or pleated domains. g. how a hormone might bind to its receptor). 4). The precursor peptide, called a pre-prohormone, carries a lipophilic signal peptide at the amino terminus. This sequence is recognized by channel proteins so that the immature peptide can cross the ER membrane. 4a–d).
G. g. g. 1 The different classes of hormone receptor. g. the parathyroid hormone (PTH) receptor, can link to different G-proteins, which couple to either adenylate cyclase or phospholipase C (PLC). g. calcitriol stimulating hormone; LH, luteinizing hormone; FSH, follicle-stimulating hormone; ACTH, adrenocorticotrophic hormone; PTHrP, parathyroid hormone-related peptide; PGE2, prostaglandin E2; GHRH, growth hormone releasing hormone; IGF-I, insulin-like growth factor I. g. g. 2 A membrane-spanning cell-surface receptor.
The individual steps between squalene and cholesterol have been omitted. synthesize them as required. As a consequence, there is a slower onset of action for steroid hormones following the initial stimulation of the steroidogenic organ. Hormone transport Most peptide hormones are hydrophilic, so they generally circulate free in the bloodstream with little or no association with serum proteins. In contrast, steroid hormones and thyroid hormones circulate bound to proteins because, like cholesterol, they are hydrophobic.