By Barbara J. Bain
This well known notebook has been up to date and multiplied all through, offering a concise view of diagnostic haematology, in a handy and functional format.A Beginner's advisor to Blood Cells is a perfect for;Trainee laboratory technicians and scientists scholars learning the body structure or pathology of the blood these getting ready for haematology examinationsWhy purchase This Book?Unique pocket consultant, written via Barbara Bain – a world-renowned professional within the box of blood morphology Outlines the fundamentals of diagnostic haematology contains a useful self-assessment part new version – now contains additional info on scientific points and additional assessments
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Extra resources for A Beginner's Guide to Blood Cells, Second Edition
Sample text
Large numbers of atypical lymphocytes, similar to those seen in infectious mononucleosis, can also occur in infection by cytomegalovirus, hepatitis A virus and adenovirus and during the parasitic infection, toxoplasmosis. Smaller numbers of atypical lymphocytes are seen in many other viral, bacterial, rickettsial and protozoan infections. Other reactive changes, in addition to those typical of infectious mononucleosis, occur in lymphocytes both during infection and during exposure to other antigenic stimuli.
7). This is known as right shift. Neutrophils with six or more lobes are said to be hypersegmented. Neutrophil hypersegmentation is an important clue to the presence of deficiency of vitamin B12 or folic acid. Macropolycytes (Fig. 8) should not be confused with hypersegmented neutrophils: they are twice the size of normal neutrophils and the nucleus is twice as big. This is because one cell division has been missed during neutrophil production. Macropolycytes are likely to have 92 Fig. 6 A neutrophil with two very round lobes in a patient with the congenital Pelger–Huët anomaly.
Less often, increased numbers of lymphocytes showing a variable degree of morphological abnormality are indicative of a neoplastic process, either a lymphoid leukaemia or a lymphoma (see Chapter 4). The most striking reactive changes in lymphocyte morphology are seen in infectious mononucleosis, an illness caused by an acute infection by the Epstein–Barr (EB) virus. There is lymphocytosis and lymphocytes are morphologically very abnormal (Fig. 9). Some are very large, some have primitive nuclei with a diffuse chromatin pattern and nucleoli, some nuclei are lobulated, some cells have voluminous basophilic cytoplasm.