Personal security : keeping yourself and your family safe : by Jackson Rosalind

By Jackson Rosalind

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Proc Nat! Acad Sci USA 96: 3751-3756 20. Zerial M (1998) Editorial overview. Curr Opin Cell Bioi 10: 475-476 21. Jackson T (1998) Transport vesicles: coats of many colours. Curr Bioi 8: R609-R612 22. Chen HJ, Yuan J, Lobel P (1997) Systematic mutational analysis of the cation-independent mannose 6-phosphate/insulin-like growth factor II receptor cytoplasmic domain. J Bioi Chern 272: 7003-7012 23. Le Borgne R, Hoflack B (1998) Protein transport from the secretory to the endocytic pathway in mammalian cells.

5 Salicylhydroxamic Acid Inhibition Hydroxamic acids are potent inhibitors of mammalian, plant and fungal peroxidases. Salicylhydroxamic acid (SHA; Fig. 4) is an analogue of the aromatic peracids that can substitute for hydrogen peroxide in promoting compound I formation in the heme peroxidases [10]. SHA is also representative of a wide range of aromatic alcohols and amines which can act as reducing substrates for compound I [10]. SHA can 4 X-Ray Crystallographic Studies of Human Myeloperoxidase 35 Fig.

It seems likely that proteins destined for storage in granules must be concentrated as cargo already in transport vesicles for further aggregation leading to the condensation state necessary for granule formation. In analogy with sorting of neuroendocrine prohormones [191, a selective aggregation during transfer through the secretory pathway, probably in the TGN, could result in sorting. Ifheterogeneous aggregates, consisting of several types of granule proteins, are formed, only a few of the proteins have to bind specifically to the TGN membrane and thereby signal for formation and budding of transport vesicles.

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