By Herbert Fleisch
This ebook is a necessary instruction manual on bisphosphonates, the main favourite new category of gear for osteoporosis remedy. It stories simple body structure as well as the indicators and adversarial reactions of those medicines. Bisphosphonates in Bone disorder, 4E, discusses the compounds' chemistry, mechanisms of motion, and animal toxicology sooner than featuring a scientific photo of the illnesses handled by way of bisphosphonates. The booklet presents a desk directory the exchange names of the commercially to be had bisphosphonates, registered symptoms, and the on hand kinds for numerous international locations. The revised Fourth variation includes nearly 50% new fabric, together with info on all the most modern medicines. * The revised fourth version includes nearly 50% new fabric* contains details on all of the most recent medicinal drugs
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Extra info for Bisphosphonates in Bone Disease: From the Laboratory to the Patient
Example text
All these effects are related to the marked affinity of these compounds for solid-phase calcium phosphate, on the surface of which they bind strongly. This property is of great importance, because it is the basis for the use of these compounds as skeletal markers in nuclear medicine and the basis for their selective localization in bone when used as drugs. Effects on calcium phosphate 9Bind stronglyto crystals 9Inhibit crystal formation 9Inhibit crystal aggregation 9Inhibit crystal dissolution Fig.
233-245. (San Diego, London: Academic Press) Lorenzo, J. , and Raisz, L. G. (1999). Cytokines and prostaglandins. In Seibel, M. , Robins, S. , and Bilezikian, J. P. ) Dynamics of Bone and Cartilage Metabolism, pp. 97-109. (San Diego, London: Academic Press) Manolagas, S. , and Jilka, R. L. (1995). Bone marrow, cytokines, and bone remodeling. N. Engl. J. Med. 332, 305-311 Martin, T. , Findlay, D. , and Moseley, J. M. (1996). Peptide hormones acting on bone. , and Kelsey, J. ) Osteoporosis, pp. 185-204.
The bisphosphonates can be divided into two groups. The nitrogencontaining compounds can inhibit the mevalonate pathway and hence inhibit protein prenylation. Others, like etidronate, clodronate, and tiludronate, can be incorporated in ATP-containing compounds. Both may act by inhibiting cell function and inducing apoptosis. Indirect effect through other cells It is likely that bisphosphonates act, at least in part, also through other cells. One candidate is the osteoblast. It is now generally accepted that 45 2.