Streptozotocin: Uses, Mechanism of Action and Side Effects by Elizabeth L. Gauthier

By Elizabeth L. Gauthier

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Extra resources for Streptozotocin: Uses, Mechanism of Action and Side Effects

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537, 106-110. , Ashe, K. , Stanley, H. , Irizarry, M. C. and Hyman, B. T. (2002) Neurotoxic effects of thioflavin S-positive amyloid deposits in transgenic mice and Alzheimer's disease. Proc. Natl. Acad. Sci. USA. 99, 13990-13995. , Qiu, W. , Rosner, M. R. and Selkoe, D. J. (2000) Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme. J. Neurosci. 20, 1657-1665. Walsh, D. M. and Selkoe, D. J. (2004) Deciphering the molecular basis of memory failure in Alzheimer's disease.

97-103. , Alpha-lipoic acid upregulates antioxidant enzyme gene expression and enzymatic activity in diabetic rat kidneys through an O-GlcNAc-dependent mechanism. Eur J Nutr. 52(5): p. 1461-73. 34 Jing Zhang and Laura R. , Induction of diabetes with signs of autoimmunity in primates by the injection of multiple-low-dose streptozotocin. Biochem Biophys Res Commun. 412(2): p. 373-8. , Combination of high-fat diet-fed and low-dose streptozotocintreated rat: a model for type 2 diabetes and pharmacological screening.

The different sensitivity of GLUT2 expressing cells results from the different levels of GLUT2 expression [8]. Therefore, using the lowest possible dose of STZ to induce diabetes is very critical in studying the diabetes and complications in an accurate way without causing additional non-diabetic symptoms. Through decades of diabetes research, the toxicity mechanism and mode of action of STZ was found to be multifaceted. Basically, the cytotoxicity of STZ was proposed to be related to its capacity to affect the insulin secretion function of pancreatic beta cells, particularly by inducing DNA damage and affecting DNA synthesis [45].

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