By John P. H. Wilding
After 3 introductory chapters that take care of the final topic of weight problems – now considered as a protracted sickness – this quantity discusses the medication sibutramine and orlistat, that are licensed for long term use within the US and in a lot of the remainder of the realm. the 3 ultimate chapters talk about destiny drug ambitions, just like the vital apprehensive process and intestine hormones, and the way to persuade power expenditure and substrate usage.
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2002) Characterization of a novel endocannabinoid, virodhamine, with antagonist activity at the CB1 receptor. J Pharmacol Exp Ther 301: 1020–1024 73 Ravinet Trillou C, Delgorge C, Menet C, Arnone M, Soubrie P (2004) CB1 cannabinoid receptor knockout in mice leads to leanness, resistance to diet-induced obesity and enhanced leptin sensitivity. Int J Obes Relat Metab Disord 28: 640–648 74 Williams CM, Rogers PJ, Kirkham TC (1998) Hyperphagia in pre-fed rats following oral delta 9THC. Physiol Behav 15: 343–346 75 Williams CM, Kirkham TC (1999) Anandamide induces over-eating: mediation by central cannabinoid (CB1) receptors.
Administration of CART inhibits NPY-induced feeding [60] while central infusion of anti-CART antibodies increases food intake [60–62]. Additionally, peripheral administration of leptin to obese rodents results in increased ARC CART mRNA expression [60]. However, the precise role of CART remains difficult to determine in the light of some experimental results. For example, the peptide fragments CART(82–103) and CART(55–102) only transiently decrease NPY-induced feeding. Furthermore, CART null mice only become obese when fed a highcalorie diet [63].
Furthermore, 5-HT2C specific antagonists inhibit the hypophagic actions of sibutramine and other 5-HT enhancing drugs. While most of the focus on 5-HT and weight control has been on drugs agonising the 5-HT2C receptor, other targets in the 5-HT system exist. The 5-HT6 receptor is one of the most recent additions to the 5-HT receptor family. It is almost exclusively expressed within the CNS with high levels in cortical and limbic regions [104]. The recent development of specific 5-HT6 ligands has indicated potential roles for this receptor in a number of physiological processes, including feeding [105].