Neural and metabolic control of macronutrient intake by Hans-Rudolf Berthoud, Randy J. Seeley

By Hans-Rudolf Berthoud, Randy J. Seeley

"Neural and Metabolic keep watch over of Macronutrient consumption systematically discusses the identified physiological mechanisms focused on macronutrient choice, together with their molecular, genetic, and neurochemical elements. This publication is usually a severe evaluate of the speculation that ingestion of the 3 macronutrients (fat, protein, carbohydrates) is regulated by means of separate neural regulate mechanisms, leaving open the prospect that concepts can be devised to interfere in physically keep an eye on structures and change the share of fats within the diet."--BOOK JACKET. learn more... content material: Sect. I. proof for macronutrient choice: uncomplicated mechanisms and techniques to accomplish rules. Ch. 1. particular Appetites and Homeostatic structures / Edward M. Stricker. Ch. 2. Too many selections? A serious Essay on Macronutrient choice / Mark I. Friedman. Ch. three. Is There a particular urge for food for Protein? / Bennett G. Galef, Jr. Ch. four. Geometric types of Macronutrient choice / Stephen J. Simpson and David Raubenheimer. Ch. five. Macronutrient choice in Free-Feeding people: facts for long term legislation / John M. de Castro. Ch. 6. Macronutrient-Specific Hungers and Satieties and Their Neural Bases, Learnt from Pre- and Postingestional results of consuming specific Foodstuffs / David A. sales space and Louise Thibault. summary: "Neural and Metabolic regulate of Macronutrient consumption systematically discusses the identified physiological mechanisms curious about macronutrient choice, together with their molecular, genetic, and neurochemical features. This publication can be a severe assessment of the speculation that ingestion of the 3 macronutrients (fat, protein, carbohydrates) is regulated by means of separate neural keep an eye on mechanisms, leaving open the chance that ideas will be devised to interfere in physically keep an eye on structures and change the share of fats within the diet."--BOOK JACKET

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And Simpson, S. , Nutr. Res. , 10, 151, 1997. ) describes a rule of compromise that quantifies the relationship between the mechanisms regulating intake of the nutrients concerned. Raubenheimer and Simpson8 and Simpson and Raubenheimer12 provide detailed discussions of the ways in which intake arrays can be described and interpreted. A key point is that such interpretations rely on there being an estimate of the position of the intake target, which provides an essential referent. Various rules of compromise have been described to date in insects and vertebrates, a selection of two-dimensional examples of which are shown in Figures 3 to 6.

When they were unable to reach the target intake they weighted protein regulation more strongly than that for carbohydrate relative to CD (where birds would have moved to the point on their food rail which lay at right angles to the target). (From Raubenheimer, D. and Simpson, S. , Nutr. Res. , 10, 151, 1997. ) © 2000 by CRC Press LLC 2752_ch04_frame Page 36 Wednesday, September 1, 1999 12:58 PM carbohydrate regulation, indicating that regulatory mechanisms for protein swamped those for carbohydrate under these circumstances.

5% protein by weight), was relatively unpalatable. Subjects were given access to bowls containing each of the four diets for 24 h/day and an experimenter simply weighed each rat and each food bowl daily. Over a 7-day period, 14 of 18 subjects failed to eat substantial amounts of the protein-rich diet and failed to gain weight (as they should have at their ages), and many were seriously ill at the end of the 7 days. The contrast with the behavior of subjects suffering sodium deprivation and offered salt solutions could not be more marked.

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