By NADIR R. FARID
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P. Increased cytosine DNA methyltransferase activity is target-cell-specific and an early event in lung cancer. Proc Natl Acad Sci USA 93, 4045–4050 (1996). 168. Issa, J. , Vertino, P. , et al. Increased cytosine DNA-methyltransferase activity during colon cancer progression. J Natl Cancer Inst 85, 1235–1240 (1993). 169. de Marzo, A. , Marchi, V. , Yang, E. , et al. Abnormal regulation of DNA methyltransferase expression during colorectal carcinogenesis. Cancer Res 59, 3855–3860 (1999). 170. , Hurteau, J.
External beam radiotherapy is advocated only for locally invasive disease. 48 2. Thyroid cancer pathology cell, a follicular epithelial cell that is characterised by abundant granular cytoplasm and a nucleus often with prominent “cherry pink” nucleolus. The background is composed of small and large lymphocytes, plasma cells, germinal centre fragments and macrophages with or without tangible bodies. Follicular cells and colloid are usually scant but may show nuclear atypia with irregular nuclear contours and prominent grooves.
Mol Cell Biol 16, 4555–4565 (1996). 172. , Issa, J. , Herman, D. , et al. Expression of an exogenous eukaryotic DNA methyltransferase gene induces transformation of NIH 3T3 cells. Proc Natl Acad Sci USA 90, 8891–8895 (1993). 173. Bakin, A. , Curran, T. Role of DNA 5-methylcytosine transferase in cell transformation by fos. Science 283, 387–390 (1999). 2. THE PATHOLOGY OF THYROID CANCER SYLVIA L. ASA Professor, Department of Laboratory Medicine & Pathobiology, University of Toronto; Pathologist-in-Chief, University Health Network and Toronto Medical Laboratories; Freeman Centre for Endocrine Oncology, Mount Sinai & Princess Margaret Hospitals; Toronto, Ontario Canada Thyroid nodules are extremely common in the general population; it has been estimated that about 20% of the population has a palpable thyroid nodule and approximately 70% has a nodule that can be detected by ultrasound (1).