By Claude Kordon, Rolf-Christian Gaillard, Yves Christen
Peripheral hormones have an incredible effect at the mind: they can intervene with its improvement, to impact liberate of neurotransmitters and concentrations of receptors, to set off development elements focused on lesion fix. those a number of activities account for his or her capability to modulate a few physiological parameters, from reproductive services to reminiscence, behaviour and getting older. This ebook established on contributions of pioneer investigators within the box, outlines the role of hormones in pathogenic procedures reminiscent of psychological disturbances or neurodegenerative diseases.
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2000). , 2003) providing a basis for Cripto upregulation in tumors. , 2000). , 1999). , 2002). We and others have recently demonstrated that Cripto can antagonize activin signaling (see Figure 1; Adkins, et al. 2003; Gray et al. 2003), providing an additional mechanism by which Cripto may promote tumorigenesis (Shen 2003). We have shown that Cripto forms a complex with activin-A and type II activin receptors that is mutually exclusive with binding of activin-A to ALK4 (Gray et al. 2003). Our data indicated that the EGF-like domain of Cripto was required for activin-A binding to Cripto, whereas mutations in the CFC domain previously shown to block Cripto binding to ALK4 did not prevent activin-A binding to Cripto (Gray et al.
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