By G. Magel, et. al.
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Extra resources for Herpesviridae - A Look Into This Unique Family of Viruses
Sample text
Herr, W. (2003). The herpes simplex virus VP16-induced complex: the makings of a regulatory switch. Trends in Biochemical Science 28 (6), pp294-304. ; Decker, L. ; Chiocca, E. ; & Saeki, Y. (2006). Imaging immediate-early and strict late promoter activity during oncolytic herpes simplex virus type 1 infection and replication in tumors. Gene Therapy 13(24), pp1731-1736. 3 Trojan Horses and Fake Immunity Idols: Molecular Mimicry of Host Immune Mediators by Human Cytomegalovirus Juliet V. Spencer University of San Francisco United States of America 1.
4. The procedure of the evolutionary simulation. Optimal Gene Expression for Efficient Replication of Herpes Simplex Virus Type 1 (HSV-1) 37 But the genotype of HSV-1 with large E and or small L is not always advantageous. There is a condition for the evolution of the temporally ordered HSV-1 gene expression. It is also shown by the evolutionary simulation that the long waiting time for the virion release is necessary to evolve the preceding expression of the early gene to that of the late gene.
The intracellular replication cycle of HSV-1. The replication of HSV-1 has started when the genome DNA of HSV-1 invades into the cell. First, the immediate early gene is expressed within 30 min. after infection. Under the control of the immediate early gene, both the early and the late gene are expressed. Early and late gene products contribute to the genome DNA replication and virion assembly, respectively. Finally, the complete virion is newly produced. 32 Herpesviridae – A Look into This Unique Family of Viruses The replication process of HSV-1 is described as a chemical reaction equation as follows: I [DNA] [DNA] [RNA I ] β I [RNA I ] [Immediate] δ RNAI [RNA I ] degradation δ I [Immediate] degradation γ E [DNA] [Immediate] [DNA] [Immediate] [RNA E ] β E [RNA E ] [Early] δ RNAE [RNA E ] degradation δ E [Early] degradation α 1 2[DNA] [Early] [DNA] [Early] γ L [DNA] [Immediate] [RNA L ] [DNA] [Immediate] β L [Late] [RNA L ] δ RNAL [RNA L ] degradation δ L [Late] degradation α 2 [DNA] [Late] [virion] δ v [virion] degradation The time change of each viral component is given according to law of mass action.