By Philip E. Harris, Pierre-Marc G. Bouloux
For a self-discipline spanning a large spectrum of stipulations and problems, it is a textbook which gives updated recommendations and help. The practising endocrine clinician will locate state of the art info in a realistic layout, in addition to aid with regimen administration matters and different difficulties which can come up much less usually. whereas the emphasis is firmly on evaluate, research and remedy, the authors have incorporated a few uncomplicated technological know-how tenets, for comprehension and completeness. they've got increased these tenets in components the place present learn is probably going to impinge upon medical perform. Endocrinology in scientific perform is perfect for all endocrinologists and people in inner medication
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Resolve within 2–3 weeks of completion Hypopituitarism—very frequent. Variable onset, but usually >12 months after treatment. 14 Typical isodose plan for irradiation of a pituitary adenoma, using a 6-MV linear accelerator. (From Plowman PN. Radiotherapy in acromegaly. In: Wass JAH, ed. Treating Acromegaly. 17 Stereotactic radiotherapy further minimizes the radiation dose to a given area of the brain and may be used in the rare instances where a tumor recurs despite a conventional course of radiotherapy.
In addition, drug administration is simplified for patients who are unable to self-inject. 52 From the cost point of view, octreotide, octreotide LAR and lanreotide are closely comparable. Overall, it seems to be appropriate to offer a long-acting formulation to patients. A major problem with conventional octreotide is patient compliance. Depot preparations have an obvious advantage in this regard. The cost of treatment with the different preparations is comparable. 9). 38 acute side-effect is abdominal colic, which may occasionally be severe.
Front Horm Res 1996; 20: 179–93. 46. Boggild MD, Jenkinson S, Pistorello M et al. Molecular genetic studies of sporadic pituitary tumors. J Clin Endocrinol Metab 1994; 78: 387–92. 47. Chandrasekharappa SC, Guru SC, Manickam P et al. Positional cloning of the gene for multiple endocrine neoplasia-type 1. Science 1997; 276: 404–7. 48. Weinberg RA. Tumor suppressor genes. Science 1991; 254: 1138–46. 49. Wynford-Thomas D. Molecular genetics of thyroid cancer. Current Opin Endocrinol Diabetes 1995; 2: 429–36.