By Carla J. Greenbaum, Leonard C. Harrison
Diabetes has garnered all over the world realization and learn investment as clinicians and researchers search to higher comprehend its pathogenesis, prevention, problems administration, and influence and dating to different ailments (heart illness, kidney illness, infections, and inflammation). Clinicians are crushed with speedily evolving advancements in regards to the technology and scientific administration of diabetes and are suffering to appreciate and practice new diabetes info.
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Extra resources for Diabetes: Translating Research into Practice
Example text
Have IDDM ? Diabetes Care 1993; 16(5):841–842. 79. Pociot F, McDermott MF. Genetics of type 1 diabetes mellitus. Genes Immun 2002; 3(5):235–249. 80. Ronningen KS, Keiding N, Green A. Correlations between the incidence of childhood-onset type I diabetes in Europe and HLA genotypes. Diabetologia 2001; 44(Suppl 3):B51–B59. 81. Rich SS. Mapping genes in diabetes. Genetic epidemiological perspective. Diabetes 1990; 39(11):1315–1319. 82. Roach JC, Deutsch K, Li S, et al. Genetic mapping at 3-kilobase resolution reveals inositol 1,4,5-triphosphate receptor 3 as a risk factor for type 1 diabetes in Sweden.
High-density genotyping within the MHC has identified a non-HLA candidate gene, inositol 1,4,5-triphosphate receptor 3 (ITPR3), as a strong candidate contributing to T1D risk (82). ITPR3 mRNA and ITPR3 protein are rapidly upregulated in pancreatic -cells following stimulation with glucose and the protein is then rapidly degraded in proteasomes. Further, the double ITPR2/ITPR3 knockout mouse is reported to be hypoglycemic and lean and to have impaired exocrine function. Thus, multiple genes in the MHC (HLA and non-HLA) may contribute to T1D risk.
SPK SPK H4371_c02 IHUSXXX-Greenbaum-H4371 36 July 10, 2008 21:0 Char Count= Sale and Rich 83. Bennett ST, Lucassen AM, Gough SC, et al. Susceptibility to human type 1 diabetes at IDDM2 is determined by tandem repeat variation at the insulin gene minisatellite locus. Nat Genet 1995; 9(3):284–292. 84. Julier C, Lucassen A, Villedieu P, et al. Multiple DNA variant association analysis: Application to the insulin gene region in type I diabetes. Am J Hum Genet 1994; 55(6):1247–1254. 85. Marchand L, Polychronakos C.