By R.D.G. Leslie, Paolo Pozzilli
The 7th overseas Barts Symposium was once hung on April 20, 2001, in London. This monograph summarizes the court cases of that convention, which shed new mild on treatments used for sort 2 diabetes. The members are world-renowned specialists within the box, and so they supply incisive statement of their respective specialties. Chapters tackle new advancements within the management of insulin, together with oral arrangements and long-acting insulin analogue. Breakthroughs within the knowing of the pathogenesis of sort 2 diabetes also are mentioned, besides the way forward for the glitazones in administration. altering treatments for kind 2 Diabetes is key for diabetologists, basic practitioners, cardiologists, geriatricians, and experts in inner medication.
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Example text
In that study, nearly 18% of adults with known CHD had a second event during a 5–7-year period of observation. Diabetic participants without known CHD actually had slightly higher rates of disease (approaching 20%) over the same observation period. The relationship between serum cholesterol, especially low-density lipoprotein (LDL) cholesterol, to heart disease among diabetic patients may be continuous. 8 For example, patients with mean LDL cholesterol levels of 93 mg/dl experience 37% more CHD than those with mean LDL concentrations of 70 mg/dl.
There may be a ‘diabetic dyslipidemia’, but it primarily manifests itself as hypertriglyceridemia rather than as high cholesterol levels. 10 On the other hand, triglyceride concentrations are elevated and there may be slight (but clinically very important) reductions in highdensity lipoprotein (HDL) cholesterol. 4 In a prospective observational study, participants with diabetes who had no previous history of coronary heart disease had about the same risk of experiencing a coronary event as non-diabetic participants who had established heart disease before they entered the observational study.
Furthermore, we now have one example in which the approach has proved its worth with the identification of CAPN-10 as a novel type 2 diabetessusceptibility gene. 02 15/03/2002 9 11 am Page 33 The molecular genetics of type 2 diabetes 33 Acknowledgements The author would like to acknowledge Diabetes UK for financial support over the years. The Diabetes UK Warren Type 2 Diabetes genome scan was a collaborative effort between McCarthy (Imperial and Oxford), Hattersley (Exeter), Hitman (St Bartholomew’s and the Royal London Hospital), Walker (Newcastle), O’Rahilly (Cambridge), the late Turner (Oxford), Levy (Oxford) and Menzell (Oxford).