Basic mechanisms of cellular secretion by Arthur R Hand; Constance Oliver; National Institute of

By Arthur R Hand; Constance Oliver; National Institute of Dental Research (U.S.)

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Discussion . . References . . 54 I. 54 55 55 56 56 57 57 58 58 67 70 Introduction Parathyroid hormone (PTH), a polypeptide of 84 amino acids whose principal physiological actions are to maintain calcium levels in the extracellular fluid, is 51 Copynghl 8 IY81 by Academic Press, Inc All rights of reproduction in any form reserved. ISBN 0-12-5M123-0 52 JOEL F . HABENER et al. synthesized by way of two successive cleavages of NH,-terminal sequences from a larger precursor, pre-proparathyroid hormone (Pre-ProPTH) of 1 15 amino acids (Habener and Potts, 1978; Habener and Kronenberg, 1978) (Fig.

1979). Cell 17, 759-769. Ewenstein, B. , Freed, J . ,Mole, L. , and Nathenson, S . G. (1976). Pruc. Natl. Acad. Sci. A. 73, 915-918. , and Soderland, H. (1978). J. Mol. B i d . 124, 535-549. , Simons, K . , and Dobberstein, B. (1978). J. M u / . Biul. 124, 587-600. 2. , and Kornfeld, S. (1979). J. Eiol. Chern. 254, 3600-3607. , Milner, R. , and Edelman, G. M. (1976). Proc. Nud. Acad. Sci. A. 73, 118-122. Hunt, L. A . , Etchinson, J. , and Summers, D. F. (1978). Proc. Nail. Acad. Sci. A. 75, 754-758.

REFERENCES Bretz, R . , and Palade, G. E. (1980). J . Cell Biul. 84, 87-101. , Lodish, H. , and Schlesinger, M. J. (1975), Cell 6,215-222. Clegg, J. C. , and Kennedy, S. I. T. (1975). J . Mol. Biul. 97, 401-41 I . , Scheele, G . , and Blobel, G . (1975). Pruc. Narl. Acad. Sci. A. 72, 5016-5020. , and Warren, G. (1979). Cell 17, 759-769. Ewenstein, B. , Freed, J . ,Mole, L. , and Nathenson, S . G. (1976). Pruc. Natl. Acad. Sci. A. 73, 915-918. , and Soderland, H. (1978). J. Mol. B i d . 124, 535-549.

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