By Andrzej Bartke, Andrew Constanti
This textbook has been written essentially for undergraduate scholars of pharmacy, toxicology, and drugs who require a concise reference ebook on easy endocrine functionality and disorder.
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Extra resources for Basic Endocrinology for Students of Pharmacy and Allied Health Sciences
Sample text
Excess prolactin may also directly interfere with gonadotrophin action on the gonads, resulting in a functional hypogonadism; the outcome will be menstrual dysfunction (amenorrhoea) and infertility; (decreased libido, impotence and infertility in men). There is growing evidence that when hypogonadism develops, the risk of osteopenia (low bone mass) also increases. Answer 3: Treatment with a dopamine D2 receptor agonist such as bromocriptine is the initial choice for management of microprolactinomas (tumours <10 mm in size).
Stimulation of prolactin release by vasoactive intestinal peptide (VIP). EurJ Pharmacol, 51, 319–320. • Rudman D, et al. (1990). Effects of human growth hormone in men over 60 years old. New Engl J Med, 323, 1–6 • Strobl JS, Thomas MJ. (1994). Human growth hormone. Pharmacol Rev, 46, 1–34 • Wintzen M, Gilchrest BA. (1996). Proopiomelanocortin, its derived peptides, and the skin . J Invest Dermatol, 106, 3–10 • Woodruff TK, Mayo KE. (1990). Regulation of inhibin synthesis in the rat ovary. Annu Rev Physiol, 52, 807–821 • Zeidel ML.
Peptides are also produced locally in the skin by melanocytes and keratinocytes, and may therefore be important for maintaining normal skin functions. 6). Pharmacological inhibition of release can also be produced by administration of synthetic corticosteroid analogues. ). g. trauma, pain, fear or hypoglycaemia (low blood sugar level) and also by the posterior pituitary peptide vasopressin. The latter may, in fact, act synergistically with CRH to regulate ACTH release from pituitary cells. Hyposecretion of ACTH (rare) causes failure of cortisol secretion, a general lack of health and well being, a reduced response to stress and skin depigmentation.