The Metabolic Syndrome: Epidemiology, Clinical Treatment, by Barbara C. Hansen, George A. Bray

By Barbara C. Hansen, George A. Bray

This e-book covers an important medical and bench technology features of metabolic syndrome. will probably be of price to all of these looking a finished replace at the metabolic syndrome. in addition, it's going to offer a large foundation for advancing study within the a number of intersecting disciplines encompassed via the metabolic syndrome.

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Extra info for The Metabolic Syndrome: Epidemiology, Clinical Treatment, and Underlying Mechanisms (Contemporary Endocrinology)

Example text

The proinfiammatory factor currently attracting the most attention as indicating increased CVD risk is C-reactive protein (CRP), but there is a much longer history of a relationship between an increase in white blood count (WBC) and heart disease. Indeed, data from the Women's Health Initiative Observational Study suggest that a high WBC was comparable in magnitude as a predictor of CVD risk to increases in CRP concentration (68). 005). These observations provide evidence that the additional CVD risk factors considered to be present in patients diagnosed as having the MetS are significantly related to both insulin resistanceihyperinsulinemia as well as the other components of the MetS.

Thus, although we may be a powerful predictor of clinical outcomes linked to insulin resistance, there is also considerable evidence that overall obesity, as estimated by BMI, not only contributes to insulin resistance, but also increases the likelihood that an individual will develop the clinical syndromes associated with the defect in insulin action. IS THERE CLINICAL UTILITY IN DIAGNOSING THE METS? 3), the components listed in each of them are remarkably similar in that they are significantly associated with insulin resistance and increased eVD risk.

28. Olefsky JM, Farquhar JW, Reaven GM. Reappraisal of the role of insulin in hypertriglyceridemia. Am J Med 1974; 57:551-560. 29. Reaven GM. The insulin resistance syndrome. Curr Atheroscler Rep 2003; 5:364-371. 30. Laws A, Reaven GM. Evidence for an independent relationship between insulin resistance and fasting plasma HDL-cholesterol, triglyceride and insulin concentrations. J Int Med 1992; 231 :25-30. 31. Reaven GM, Chen Y-DI, Jeppesen J et al. Insulin resistance and hyperinsulinemia in individuals with small, dense, low density lipoprotein particles.

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