Astrocytes and Epilepsy by Jacqueline A. Hubbard, Devin K. Binder

By Jacqueline A. Hubbard, Devin K. Binder

Epilepsy is a devastating workforce of neurological problems characterised through periodic and unpredictable seizure job within the brain.  there's a serious want for brand spanking new medicinal drugs and techniques given than not less than one-third of all epilepsy sufferers usually are not made freed from seizures by way of current medicines and turn into "medically refractory".  a lot of epilepsy study has all for neuronal healing pursuits, yet present antiepileptic medicinal drugs usually reason serious cognitive, developmental, and behavioral negative effects. fresh findings point out a serious contribution of astrocytes, star-shaped glial cells within the mind, to neuronal and community excitability and seizure activity.  moreover, many very important mobile and molecular alterations ensue in astrocytes in epileptic tissue in either people and animal versions of epilepsy.  The aim of Astrocytes and Epilepsy is to comprehensively assessment intriguing findings linking adjustments in astrocytes to useful adjustments accountable for epilepsy for the 1st time in booklet format.  those insights into astrocyte contribution to seizure susceptibility point out that astrocytes may well symbolize a tremendous new healing goal within the regulate of epilepsy. 

Astrocytes and Epilepsy contains history explanatory textual content on astrocyte morphology and body structure, epilepsy versions and syndromes, and facts from either human tissue reports and animal types linking sensible adjustments in astrocytes to epilepsy.  superbly labelled diagrams are provided and correct figures from the literature are reproduced to clarify key findings and ideas during this speedily rising field.  Astrocytes and Epilepsy is written for neuroscientists, epilepsy researchers, astrocyte investigators in addition to neurologists and different experts taking care of sufferers with epilepsy.

  • Presents the 1st finished e-book to synthesize historic and up to date study on astrocytes and epilepsy into one coherent volume
  • Provides a very good source at the box of astrocyte biology and astrocyte-neuron interactions
  • Details capability healing ambitions, together with chapters on hole junctions, water and potassium channels, glutamate and adenosine metabolism, and inflammation

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B) Typical human protoplasmic astrocyte in the same scale. Scale bar, 20 µm. 005, t test).

197–222. Given the morphological and functional heterogeneity of astrocytes, identification of “classical” astrocytes requires careful consideration. Kimelberg put forth the following criteria [14,15]: 1. Absence of electrical excitability 2. Very negative membrane potential (−80 to −90 mV) 3. Expression of neurotransmitter transporters (GABA, glutamate) 4. 4 Morphological diversity of astrocytes. Ia, pial tanycyte; Ib, vascular tanycyte; II, radial astrocyte (Bergmann glial cell); III, marginal astrocyte; IV, protoplasmic astrocyte; V, velate astrocyte; VI, fibrous astrocyte; VII, perivascular astrocyte; VIII, interlaminar astrocyte; IX, immature astrocyte; X, ependymocyte; XI, choroid plexus cell.

What I saw was difficult to interpret” [79]. In a short 6 months in Madrid, not only did Penfield perfect a specific stain for oligodendroglia and describe this “third element” in the seminal 1924 Brain paper, but with Río-Hortega also moved from “pure” neuroscience to neuropathology in studying the reaction of glial cells to injury. In an article entitled “Cerebral cicatrix: the reaction of neuroglia and microglia to brain wounds” [73], they provide several observations regarding cellular changes following simple stab wounds: The formation of a simple cicatrix in the brain presents the following stages: The first cellular change is observed in microglia cells which begin their phagocytic activity early and continue it for a long period.

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