Advances in Bioengineering by Pier Andrea Serra

By Pier Andrea Serra

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Typical AFM resolutions are well below 1 nm. AFM can be used to study the way plasma polymers grow: AFM images have been used to show the surface morphology of the deposited films while varying the treatment time [66]. AFM analysis is useful, not only in a qualitative way but also for quantitative determinations, since it allows a 3D representation of the treated surface and quantifies the effects of the plasma-etching mechanism by calculation of the surface roughness (root-mean-squared roughness, Rrms) [44].

This study is intended to broaden the scope of 50 Advances in Bioengineering Figure 1. Thermal polymerization of amino acids through pyroglutamic acid catalysis. biodegradable polymers by synthesizing new proteinoids carrying various stereogenic centers. The main goal is to provide a large choice of biodegradable proteinoids with predetermined characteristics, while using amino acids as building blocks. Hence, the new selection is based on chiral building blocks carrying positive/negative charge, hydrophilic/ hydrophobic nature or any desired combination of the above [16].

Anchorage-dependent cells such as fibroblasts and osteoblasts need the adhesion for cell growth, division and spreading [79]. It was found that attachment, proliferation and function of these anchorage-dependent cells are highly dependent on the surface properties of biomaterials [80]. The variation of biocompatibility after amine plasma treatment of many biomaterials has been studied by the means of fibroblast and osteoblast cell cultures. Wen-Juan et al. [71] and Ren et al. [81] modified silicon surfaces with allylamine dielectric barrier discharge and microwave plasma respectively.

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